Peptide Lab HQ Research Guide
Semax
A research-focused compound profile covering Semax identity, ACTH-fragment research, neuroprotective peptide models, cognitive signaling, concentration reference, reconstitution reference, and safety considerations.
Compound Data
Compound Profile
| Compound Name | Semax |
|---|---|
| Compound Type | Synthetic heptapeptide / ACTH(4–10) analog |
| CAS Number | 80714-61-0 |
| PubChem CID | 122178 |
| Amino Acid Length | 7 amino acids |
| Amino Acid Sequence | Met-Glu-His-Phe-Pro-Gly-Pro |
| Short Sequence | MEHFPGP |
| Molecular Formula | C₃₇H₅₁N₉O₁₀S |
| Molecular Weight | Approximately 813.9 g/mol |
| Research Category | ACTH-fragment, neuroprotective, nootropic, BDNF, dopaminergic, serotonergic, and CNS peptide research |
| Appearance | White to off-white lyophilized powder |
| Use | For laboratory research use only. |
Research Applications
Key Research Applications
Semax is commonly discussed in controlled research models involving ACTH-fragment activity, neuroprotection, nootropic signaling, BDNF-related pathways, dopaminergic and serotonergic systems, stress-response models, and cognitive-performance research.
ACTH-Fragment Research
Semax is a synthetic analog of the ACTH(4–10) fragment and is commonly discussed in peptide-signaling and neurotropic research models.
Neuroprotective Models
Semax appears in research involving ischemia, oxidative stress, neuroinflammation, neuronal survival, and recovery-related CNS pathway observations.
BDNF / TrkB Pathway Context
Research literature discusses Semax in relation to neurotrophic signaling, including brain-derived neurotrophic factor and related receptor activity.
Dopaminergic Research
Semax has been studied in models involving dopaminergic-system disruption, locomotor behavior, anxiety-like behavior, and neurotoxin-related observations.
Serotonergic / Stress Models
Used in research contexts involving serotonergic signaling, stress exposure, anxiolytic-like activity, and antidepressant-like behavioral models.
Nootropic Study Context
Semax is commonly discussed in nootropic research involving attention, memory-related observations, cognitive performance, and CNS network activity.
Research Scope
These applications are provided for educational and research-reference purposes only. Research outcomes may vary based on study model, route, timing, purity, concentration, and laboratory conditions.
Reference Only
Reconstitution / Research Dosing Reference
Select Reference Vial
Select a vial size to update the concentration, U-100 unit references, and frequency table below.
Quick Reference Summary
| Reference Vial | 5 mg Semax |
|---|---|
| Primary Solution Volume | 2.0 mL bacteriostatic water |
| Primary Concentration | 2.5 mg/mL |
| Measurement Reference | On a U-100 syringe, 1 unit = 0.01 mL. |
| Amount per U-100 Unit | At 2.5 mg/mL, 1 unit equals 0.025 mg / 25 mcg Semax. |
| Storage Reference | Refrigerate at 2–8°C / 35.6–46.4°F after reconstitution, protected from direct light. |
Reconstitution Steps
- Draw 2.0 mL bacteriostatic water using a sterile syringe for the main concentration reference shown below.
- Slowly add the BAC water down the side of the vial wall.
- Gently roll or swirl the vial until the material is completely dissolved. The solution should appear clear. Do not shake!
- For higher-concentration preparations, verify that the material is fully dissolved before recording the final preparation details.
- Label with compound name, vial amount, concentration, solvent volume, preparation date, storage conditions, and handling notes.
- Store refrigerated at 2–8°C / 35.6–46.4°F, protected from direct light.
Published Research Context
| Reference Type | Reported Amount / Context | Research Notes |
|---|---|---|
| Compound Identity Reference | Semax, synthetic ACTH(4–10) analog / ACTH(4–7)-PGP | Semax is commonly discussed as a synthetic heptapeptide analog of an adrenocorticotropic hormone fragment in neuropeptide and CNS research contexts. |
| Cognitive / Neural Research Context | Model-dependent concentration and endpoint tracking | Commonly discussed in cognitive-function, learning, memory, attention-marker, stress-response, and central nervous system research models. |
| BDNF / TrkB Research Context | Neurotrophic-marker and hippocampal pathway context | Semax has been discussed in research involving BDNF / TrkB pathway activity, neurotrophic-marker response, hippocampal signaling, and cognitive-marker observations. |
| Neuroprotective Research Context | Experimental and model-dependent context | Semax-related research is often discussed in ischemia, oxidative-stress-marker, neuronal injury, neuroprotection, vascular-response, and recovery-model research contexts. |
| Gene-Expression Research Context | Preclinical and cellular-marker context | Research discussions commonly include gene-expression changes, neurotrophic-marker patterns, inflammatory-marker context, and brain-region-specific marker observations depending on the model. |
| Public Protocol-Style Reference | Microgram-to-milligram reference examples | Public protocol-style references commonly describe Semax in microgram-to-milligram examples depending on the research model and preparation format. These are not clinical dosing standards. |
| Clinical / Research-Chemical Status | No universal research-chemical protocol established | Published study references, clinical-study references, public protocol-style references, wellness protocols, or public dosing pages should not be treated as dosing instructions for research-chemical vial formats. |
Concentration Reference
| Vial Amount | Solution Volume | Final Concentration |
|---|---|---|
| 5 mg | 2.0 mL | 2.5 mg/mL |
| 10 mg | 2.0 mL | 5 mg/mL |
| 30 mg | 3.0 mL | 10 mg/mL |
Research Dosing Amount / Volume Reference
| Reference Amount | Volume at 2.5 mg/mL | U-100 Unit Reference | Approx. References per 5 mg Vial |
|---|---|---|---|
| 50 mcg | 0.02 mL | 2 units | 100 |
| 100 mcg | 0.04 mL | 4 units | 50 |
| 0.25 mg / 250 mcg | 0.10 mL | 10 units | 20 |
| 0.5 mg / 500 mcg | 0.20 mL | 20 units | 10 |
| 1 mg / 1000 mcg | 0.40 mL | 40 units | 5 |
| 2 mg / 2000 mcg | 0.80 mL | 80 units | 2.5 |
| 5 mg / 5000 mcg | 2.00 mL | 200 units | 1 |
| 10 mg / 10000 mcg | 4.00 mL | 400 units | 0.5 |
Research Frequency / Amount Reference
| Research Window | Frequency | Reference Amount | Units / Volume Reference |
|---|---|---|---|
| Lower Microgram Reference | Calculation reference only | 50 mcg reference amount | 2 units / 0.02 mL |
| Standard Microgram Reference | Public protocol-style reference, not a clinical dosing standard | 100 mcg reference amount | 4 units / 0.04 mL |
| Low Milligram Conversion Example | Public protocol-style reference, not a clinical dosing standard | 250 mcg reference amount | 10 units / 0.10 mL |
| Mid-Range Conversion Example | Calculation reference only | 0.5 mg reference amount | 20 units / 0.20 mL |
| Upper Conversion Example | Calculation reference only | 1 mg reference amount | 40 units / 0.40 mL |
| High Conversion Example | Calculation reference only | 2 mg reference amount | 80 units / 0.80 mL |
| 5 mg Preparation Reference | Preparation-level calculation reference | 5 mg reference amount | 200 units / 2.00 mL |
| 10 mg Preparation Reference | Preparation-level calculation reference | 10 mg reference amount | 400 units / 4.00 mL |
Common Research Windows
| Reference Window | Common Length | Research Notes |
|---|---|---|
| Cell-Culture / Marker Observation Window | 24–72 hours | May be used for gene-expression, neurotrophic-marker, BDNF / TrkB pathway, inflammatory-marker, cellular-response, or stress-response documentation depending on the model. |
| Acute Neurocognitive Observation Window | Single session to several days | Used for short-term cognitive-marker, stress-response, neurotrophic-marker, or early pathway tracking depending on the research design. |
| Short Research Window | 1–2 weeks | May be used for early controlled observation involving cognitive markers, learning/memory models, neuroprotection markers, or stress-response endpoints. |
| Standard Protocol-Style Window | 2–4 weeks | Commonly used in public protocol-style references for structured observation and comparison across baseline and follow-up periods. |
| Extended Observation Window | 4–8 weeks | Used when longer documentation is needed for neurocognitive trends, ischemia-model context, neuroprotective markers, or follow-up marker tracking. |
| Follow-Up / Washout | 1–4 weeks | Used to document post-study observations, marker return, delayed response patterns, or follow-up data depending on the research model. |
Research Note: These tables are provided for educational, research-planning, concentration, frequency-reference, and volume-reference purposes only. Semax is commonly discussed in ACTH-fragment analog, neuropeptide, cognitive-function, BDNF / TrkB, neuroprotective, ischemia-model, gene-expression, stress-response, and CNS marker research contexts. The selector above updates calculations for 5 mg and 10 mg vial references reconstituted with 2.0 mL bacteriostatic water, and a 30 mg vial reference reconstituted with 3.0 mL bacteriostatic water. Published study references, clinical-study contexts, and public protocol-style frequency references are not universal research-chemical dosing standards and should not be treated as dosing instructions for research-chemical vial formats. This information is not medical advice, dosing instruction, injectable-use guidance, or a recommendation for human or animal use.
Research Notes
Research Findings & Safety Notes
Research Findings
Semax is commonly discussed in research involving ACTH-fragment signaling, neuroprotection, BDNF-related pathways, dopaminergic and serotonergic systems, stress-response behavior, ischemic models, and nootropic study contexts.
Study Limitations
Semax research includes animal studies, mechanistic studies, and clinical references from specific study contexts. Findings should be interpreted according to model type, route, formulation, and study design.
Safety Considerations
Laboratory handling should include appropriate PPE, sterile technique, proper labeling, batch documentation, and qualified research procedures.
Use Restriction
Not for human or animal consumption. Not intended to diagnose, treat, cure, or prevent any disease.
Related Supplies
Research Supplies
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Bacteriostatic Water
Commonly referenced in laboratory preparation workflows.
Research Syringes
Supply category for controlled laboratory research preparation.
Prep Supplies
Supporting supplies for clean handling, preparation, and documentation.
Lab Handling
Handling & Storage
Storage
Store materials according to product-specific requirements. Protect from excessive heat, moisture, and direct light.
After Reconstitution
Keep refrigerated after reconstitution unless otherwise specified by the product documentation.
Handling
Use appropriate laboratory PPE, clean handling practices, and qualified research procedures.
Documentation
Maintain batch details, COA records, preparation notes, and internal research documentation.