Peptide Lab HQ Research Guide
IGF-1 LR3
A research-focused compound profile covering IGF-1 LR3 identity, Long R3 IGF-I pathway research, IGF-1 receptor signaling, cell-growth models, concentration reference, reconstitution reference, and safety considerations.
Compound Data
Compound Profile
| Compound Name | IGF-1 LR3 |
|---|---|
| Common Names | Long R3 IGF-I, Long Arg3 IGF-I, LR3 IGF-1 |
| Compound Type | Synthetic / recombinant insulin-like growth factor-1 analog |
| CAS Number | Commonly listed as 946870-92-4; verify against supplier COA |
| Amino Acid Length | 83 amino acids |
| Structural Modification | Complete human IGF-1 sequence with an Arg substitution at position 3 and a 13-amino-acid N-terminal extension |
| Binding Context | Engineered for reduced affinity to IGF-binding proteins while maintaining IGF-1 receptor pathway activity |
| Molecular Formula | Commonly listed as C₄₀₀H₆₂₅N₁₁₁O₁₁₅S₉; verify against supplier COA |
| Molecular Weight | Commonly listed around 9117.6 g/mol; verify against supplier COA |
| Research Category | IGF-1 receptor signaling, cell proliferation, cell survival, protein synthesis, cell-culture supplementation, biomanufacturing, and metabolic pathway research |
| Appearance | White to off-white lyophilized powder, depending on supplier documentation |
| Use | For laboratory research use only. |
Research Applications
Key Research Applications
IGF-1 LR3 is commonly discussed in controlled research models involving IGF-1 receptor signaling, cell proliferation, cell survival, protein synthesis, apoptosis resistance, low-serum culture support, serum-free culture systems, and growth-factor pathway modeling.
IGF-1 Receptor Research
IGF-1 LR3 is studied as a modified IGF-1 analog that activates Type I IGF-1 receptor-related signaling pathways in cellular research systems.
Cell-Culture Supplement Research
Long R3 IGF-I is commonly used in low-serum and serum-free cell-culture systems where growth-factor support is required.
CHO Cell Productivity Models
IGF-1 LR3 is frequently discussed in CHO-cell productivity, antibody-production, and biomanufacturing research contexts.
Cell Survival Research
Used in research involving cell viability, apoptosis resistance, growth-factor withdrawal models, and extended culture duration.
Protein Synthesis Models
Relevant to research involving anabolic signaling, protein synthesis, myoblast models, and cellular growth response.
IGF-Binding Protein Context
The LR3 modification is commonly discussed for reducing IGF-binding-protein interaction, increasing free growth-factor availability in research systems.
Research Scope
These applications are provided for educational and research-reference purposes only. Research outcomes may vary based on cell type, receptor expression, concentration, exposure duration, media composition, peptide purity, and laboratory conditions.
Reference Only
Reconstitution / Research Dosing Reference
Select Reference Vial
Select a vial size to update the concentration, U-100 unit references, and frequency table below.
Quick Reference Summary
| Reference Vial | 0.1 mg / 100 mcg IGF-1 LR3 |
|---|---|
| Primary Solution Volume | 2 mL bacteriostatic water |
| Primary Concentration | 0.05 mg/mL |
| Measurement Reference | On a U-100 syringe, 1 unit = 0.01 mL. |
| Amount per U-100 Unit | At 0.05 mg/mL, 1 unit equals 0.0005 mg / 0.5 mcg IGF-1 LR3. |
| Storage Reference | Refrigerate at 2–8°C / 35.6–46.4°F after reconstitution, protected from direct light. |
Reconstitution Steps
- Draw 2 mL bacteriostatic water using a sterile syringe for the main concentration reference shown below.
- Slowly add the BAC water down the side of the vial wall.
- Gently roll or swirl the vial until the material is completely dissolved. The solution should appear clear. Do not shake!
- Label with compound name, vial amount, concentration, solvent volume, preparation date, storage conditions, and handling notes.
- Store refrigerated at 2–8°C / 35.6–46.4°F, protected from direct light.
Published Research Context
| Reference Type | Reported Amount / Context | Research Notes |
|---|---|---|
| Compound Identity Reference | IGF-1 LR3, also referenced as Long R3 IGF-I / Long Arg3 IGF-I | IGF-1 LR3 is commonly discussed as an IGF-I analog with altered binding-protein interaction in cell-culture and receptor-response models. |
| Cell-Culture Research Context | Model-dependent concentration and endpoint tracking | Commonly discussed in cell growth, cell survival, cell-density, viability, and low-serum culture conditions. |
| IGF Receptor / Binding Protein Research | Reduced IGF-binding-protein interaction context | Research discussions commonly include IGF receptor signaling, survival markers, growth-factor response, and IGF-binding-protein interactions. |
| Public Protocol-Style Reference | Microgram-range reference examples | Public protocol-style references are not clinical dosing standards and should not be treated as research-chemical use instructions. |
| Clinical / Research-Chemical Status | No universal research-chemical protocol established | Published study references, public protocol-style references, clinical-use references, or wellness protocols should not be treated as dosing instructions for research-chemical vial formats. |
Concentration Reference
| Vial Amount | Solution Volume | Final Concentration |
|---|---|---|
| 0.1 mg / 100 mcg | 2 mL | 0.05 mg/mL |
| 1 mg / 1000 mcg | 2 mL | 0.5 mg/mL |
Research Dosing Amount / Volume Reference
| Reference Amount | Volume at 0.05 mg/mL | U-100 Unit Reference | Approx. References per 0.1 mg / 100 mcg Vial |
|---|---|---|---|
| 1 mcg | 0.02 mL | 2 units | 100 |
| 5 mcg | 0.1 mL | 10 units | 20 |
| 10 mcg | 0.20 mL | 20 units | 10 |
| 20 mcg | 0.40 mL | 40 units | 5 |
| 50 mcg | 1.00 mL | 100 units | 2 |
| 0.1 mg / 100 mcg | 2.00 mL | 200 units | 1 |
| 0.5 mg / 500 mcg | 10.00 mL | 1000 units | 0.2 |
| 1 mg / 1000 mcg | 20.00 mL | 2000 units | 0.1 |
Research Frequency / Amount Reference
| Research Window | Frequency | Reference Amount | Units / Volume Reference |
|---|---|---|---|
| Lower Conversion Reference | Public protocol-style reference, not a clinical dosing standard | 1 mcg reference amount | 2 units / 0.02 mL |
| Low-to-Mid Conversion Reference | Public protocol-style reference, not a clinical dosing standard | 5 mcg reference amount | 10 units / 0.1 mL |
| Standard Conversion Reference | Public protocol-style reference, not a clinical dosing standard | 10 mcg reference amount | 20 units / 0.20 mL |
| Mid-Range Conversion Example | Public protocol-style reference, not a clinical dosing standard | 20 mcg reference amount | 40 units / 0.40 mL |
| Upper Conversion Example | Public protocol-style reference, not a clinical dosing standard | 50 mcg reference amount | 100 units / 1.00 mL |
| High Conversion Example | Public protocol-style reference, not a clinical dosing standard | 0.1 mg / 100 mcg reference amount | 200 units / 2.00 mL |
Common Research Windows
| Reference Window | Common Length | Research Notes |
|---|---|---|
| Cell-Culture / Marker Observation Window | 24–72 hours | May be used for cell-growth, cell-survival, viability, signaling, or receptor-response documentation depending on the model. |
| Acute Observation Window | Single session to several days | Used for short-term response tracking, timing comparison, early marker observation, or preparation comparison depending on the research design. |
| Short Research Window | 1–2 weeks | May be used for early controlled observation involving cell proliferation, cell-density, survival-marker, or growth-factor-response endpoints. |
| Standard Protocol-Style Window | 2–4 weeks | Commonly used in public protocol-style references for structured observation and comparison across baseline and follow-up periods. |
| Extended Observation Window | 4–8 weeks | Used when longer documentation is needed for growth-factor-response trends, IGF-pathway context, or follow-up marker tracking. |
| Follow-Up / Washout | 1–4 weeks | Used to document post-study observations, marker return, delayed response patterns, or follow-up data depending on the research model. |
Research Note: These tables are provided for educational, research-planning, concentration, frequency-reference, and volume-reference purposes only. IGF-1 LR3, also commonly referenced as Long R3 IGF-I or Long Arg3 IGF-I, is commonly discussed in IGF receptor, cell-culture, cell-growth, cell-survival, IGF-binding-protein, and growth-factor pathway research contexts. The selector above updates calculations for 0.1 mg and 1 mg vial references, each reconstituted with 2.0 mL bacteriostatic water. Published study references and public protocol-style frequency references are not universal research-chemical dosing standards and should not be treated as dosing instructions for research-chemical vial formats. This information is not medical advice, dosing instruction, injectable-use guidance, or a recommendation for human or animal use.
Research Notes
Research Findings & Safety Notes
Research Findings
IGF-1 LR3 is commonly discussed in research involving IGF-1 receptor activation, cell proliferation, cell survival, protein synthesis, apoptosis resistance, serum-free cell-culture support, CHO productivity, and growth-factor pathway modeling.
Study Limitations
IGF-1 LR3 research includes cell-culture studies, biomanufacturing applications, animal infusion models, and mechanistic growth-factor research. Findings should be interpreted according to model type, receptor expression, concentration, route, exposure duration, and endpoint selection.
Safety Considerations
Research discussion should account for IGF-1 receptor activity, glucose-related markers, insulin-pathway interaction, cell-proliferation signaling, peptide purity, sterility documentation, endotoxin risk, and qualified laboratory handling procedures.
Use Restriction
Not for human or animal consumption. Not intended to diagnose, treat, cure, or prevent any disease when discussed as a research-use material.
Related Supplies
Research Supplies
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Bacteriostatic Water
Commonly referenced in laboratory preparation workflows.
Research Syringes
Supply category for controlled laboratory research preparation.
Prep Supplies
Supporting supplies for clean handling, preparation, and documentation.
Lab Handling
Handling & Storage
Storage
Store materials according to product-specific requirements. Protect from excessive heat, moisture, and direct light.
After Reconstitution
Keep refrigerated after reconstitution unless otherwise specified by the product documentation.
Handling
Use appropriate laboratory PPE, clean handling practices, and qualified research procedures.
Documentation
Maintain batch details, COA records, preparation notes, and internal research documentation.