Peptide Lab HQ Research Guide
SNAP-8
A research-focused compound profile covering SNAP-8 identity, Acetyl Octapeptide-3 research, SNARE-complex pathway models, cosmetic formulation research, concentration reference, reconstitution reference, and safety considerations.
Compound Data
Compound Profile
| Compound Name | SNAP-8 |
|---|---|
| Common Name | Acetyl Octapeptide-3 |
| Common Synonyms | SNAP-8 peptide, Acetyl Octapeptide-3, Acetyl Glutamyl Heptapeptide-3, SNAP-25 analog research peptide |
| Compound Type | Synthetic acetylated octapeptide / cosmetic formulation research peptide |
| CAS Number | Commonly listed as 868844-74-0; verify against supplier COA |
| Amino Acid Length | 8 amino acids with N-terminal acetylation and C-terminal amidation |
| Amino Acid Sequence | Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH₂ |
| Short Sequence | Ac-EEMQRRAD-NH₂ |
| Molecular Formula | Form/source-dependent; commonly listed as C₄₁H₇₀N₁₆O₁₆S or PubChem-listed Acetyl Octapeptide-3 as C₄₂H₇₂N₁₆O₁₅S |
| Molecular Weight | Form/source-dependent; commonly referenced around 1075 g/mol |
| Research Category | Cosmetic peptide, SNAP-25 analog, SNARE-complex, neuromodulatory topical, expression-line, and skin topography research |
| Appearance | White to off-white lyophilized powder |
| Use | For laboratory research use only. |
Research Applications
Key Research Applications
SNAP-8 is commonly discussed in controlled cosmetic and dermatological research models involving SNAP-25 analog activity, SNARE-complex pathway modulation, expression-line appearance, topical peptide delivery, skin topography, and formulation stability.
SNARE-Complex Research
SNAP-8 is commonly studied in relation to SNARE-complex assembly, a pathway involved in vesicle fusion and neurotransmitter-release signaling.
SNAP-25 Analog Models
Used in research involving SNAP-25-like peptide fragments, neuromodulatory cosmetic pathways, and expression-line formation models.
Expression-Line Research
SNAP-8 is commonly discussed in topical cosmetic research involving dynamic facial lines, especially in areas with repeated muscle movement.
Topical Formulation Research
Relevant to research involving peptide solubility, vehicle selection, delivery systems, skin compatibility, and formulation stability.
Skin Topography Models
Used in cosmetic research evaluating wrinkle depth, surface roughness, texture appearance, and image-based skin analysis endpoints.
Non-Invasive Peptide Research
SNAP-8 is commonly discussed alongside Argireline and other topical peptide alternatives used in non-invasive cosmetic research models.
Research Scope
These applications are provided for educational and research-reference purposes only. Research outcomes may vary based on peptide form, purity, formulation vehicle, delivery system, concentration, skin model, and laboratory conditions.
Reference Only
Reconstitution / Research Dosing Reference
Quick Reference Summary
| Reference Vial | 10 mg SNAP-8 |
|---|---|
| Primary Solution Volume | 2.0 mL bacteriostatic water |
| Primary Concentration | 5 mg/mL |
| Measurement Reference | On a U-100 syringe, 1 unit = 0.01 mL. |
| Amount per U-100 Unit | At 5 mg/mL, 1 unit equals 0.05 mg / 50 mcg SNAP-8. |
| Storage Reference | Refrigerate at 2–8°C / 35.6–46.4°F after preparation, protected from direct light. |
Reconstitution Steps
- Draw 2.0 mL bacteriostatic water using a sterile syringe for the main concentration reference shown below.
- Slowly add the BAC water down the side of the vial wall.
- Gently roll or swirl the vial until the material is completely dissolved. The solution should appear clear to slightly hazy depending on concentration and supplier format. Do not shake!
- Because SNAP-8 is commonly used in cosmetic peptide and formulation research contexts, verify solvent compatibility, solubility, and handling notes against the supplier COA, batch record, or formula record when available.
- Label with compound name, vial amount, concentration, solvent volume, preparation date, storage conditions, and handling notes.
- Store refrigerated at 2–8°C / 35.6–46.4°F, protected from direct light, unless supplier documentation specifies otherwise.
Published Research Context
| Reference Type | Reported Amount / Context | Research Notes |
|---|---|---|
| Compound Identity Reference | SNAP-8, also commonly referenced as Acetyl Octapeptide-3 | SNAP-8 is commonly discussed as a synthetic cosmetic octapeptide related to acetyl hexapeptide / Argireline-style SNARE pathway research. |
| Sequence Reference | Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH2 | This octapeptide sequence is commonly listed in peptide supplier references and chemical database entries for Acetyl Octapeptide-3 / SNAP-8. |
| SNARE / SNAP-25 Research Context | Model-dependent concentration and endpoint tracking | SNAP-8 is commonly discussed in relation to SNAP-25 mimicry, SNARE complex pathway modeling, acetylcholine-release-marker studies, and neuromuscular-signaling marker research. |
| Cosmetic Peptide Research Context | Formulation and skin-appearance marker context | Research and formulation references commonly discuss SNAP-8 in cosmetic peptide, expression-line marker, wrinkle-depth marker, and topical formulation screening contexts. |
| Skin-Model / Formulation Research | In vitro, ex vivo, or formulation compatibility context | Commonly discussed in peptide stability, formulation compatibility, skin-model response, penetration-limitation, and marker-based cosmetic research contexts. |
| Public Protocol-Style Reference | Microgram-to-milligram reference examples | Public protocol-style references may describe SNAP-8 in microgram-to-milligram examples depending on the research model and preparation format. These are not clinical dosing standards. |
| Clinical / Research-Chemical Status | No universal research-chemical protocol established | Published study references, cosmetic formulation references, public protocol-style references, or wellness protocols should not be treated as dosing instructions for research-chemical vial formats. |
Concentration Reference
| Vial Amount | Solution Volume | Final Concentration |
|---|---|---|
| 10 mg | 2.0 mL | 5 mg/mL |
Research Dosing Amount / Volume Reference
| Reference Amount | Volume at 5 mg/mL | U-100 Unit Reference | Approx. References per 10 mg Vial |
|---|---|---|---|
| 50 mcg | 0.01 mL | 1 unit | 200 |
| 100 mcg | 0.02 mL | 2 units | 100 |
| 0.25 mg / 250 mcg | 0.05 mL | 5 units | 40 |
| 0.5 mg / 500 mcg | 0.10 mL | 10 units | 20 |
| 1 mg / 1000 mcg | 0.20 mL | 20 units | 10 |
| 2 mg / 2000 mcg | 0.40 mL | 40 units | 5 |
| 5 mg / 5000 mcg | 1.00 mL | 100 units | 2 |
| 10 mg / 10000 mcg | 2.00 mL | 200 units | 1 |
Research Frequency / Amount Reference
| Research Window | Frequency | Reference Amount | Units / Volume Reference |
|---|---|---|---|
| Lower Microgram Reference | Calculation reference only | 50 mcg reference amount | 1 unit / 0.01 mL |
| Standard Microgram Reference | Calculation reference only | 100 mcg reference amount | 2 units / 0.02 mL |
| Low Milligram Conversion Example | Public protocol-style reference, not a clinical dosing standard | 250 mcg reference amount | 5 units / 0.05 mL |
| Mid-Range Conversion Example | Public protocol-style reference, not a clinical dosing standard | 0.5 mg reference amount | 10 units / 0.10 mL |
| Upper Conversion Example | Calculation reference only | 1 mg reference amount | 20 units / 0.20 mL |
| High Conversion Example | Calculation reference only | 2 mg reference amount | 40 units / 0.40 mL |
| Half-Vial Preparation Reference | Preparation-level calculation reference | 5 mg reference amount | 100 units / 1.00 mL |
| Full-Vial Preparation Reference | Preparation-level calculation reference | 10 mg reference amount | 200 units / 2.00 mL |
Common Research Windows
| Reference Window | Common Length | Research Notes |
|---|---|---|
| Cell-Culture / Pathway Observation Window | 24–72 hours | May be used for SNAP-25 mimicry, SNARE complex pathway modeling, acetylcholine-release-marker, cellular-response, or peptide-response documentation depending on the model. |
| Formulation Compatibility Window | Several days to 2 weeks | Used for short-term solubility, stability, compatibility, appearance, and peptide-integrity observations depending on the formulation design. |
| Short Skin-Model Research Window | 1–2 weeks | May be used for early controlled observation involving skin-model response, expression-line markers, peptide-response markers, or topical formulation screening. |
| Standard Protocol-Style Window | 2–4 weeks | Commonly used in public protocol-style references for structured cosmetic peptide observation and comparison across baseline and follow-up periods. |
| Extended Observation Window | 4–8 weeks | Used when longer documentation is needed for formulation stability, appearance-marker trends, skin-model response, or follow-up marker tracking. |
| Follow-Up / Washout | 1–4 weeks | Used to document post-study observations, marker return, delayed response patterns, or follow-up data depending on the research model. |
Research Note: These tables are provided for educational, research-planning, concentration, frequency-reference, and volume-reference purposes only. SNAP-8, also commonly referenced as Acetyl Octapeptide-3, is discussed in cosmetic peptide, SNARE complex, SNAP-25 mimic, acetylcholine-release-marker, expression-line marker, topical formulation, skin-model, and peptide-stability research contexts. This reference uses a 10 mg vial reconstituted with 2.0 mL bacteriostatic water, creating a 5 mg/mL concentration. Because SNAP-8 is commonly referenced in cosmetic peptide and formulation research contexts, solvent compatibility and intended preparation format should be verified against the supplier COA, batch record, or formula record when available. Published study references, cosmetic formulation references, and public protocol-style frequency references are not universal research-chemical dosing standards and should not be treated as dosing instructions for research-chemical vial formats. This information is not medical advice, dosing instruction, injectable-use guidance, or a recommendation for human or animal use.
Research Notes
Research Findings & Safety Notes
Research Findings
SNAP-8 is commonly discussed in cosmetic research involving SNAP-25 analog activity, SNARE-complex pathway modulation, expression-line appearance, wrinkle-depth observation, topical peptide delivery, and skin topography endpoints.
Study Limitations
SNAP-8 research is primarily cosmetic and formulation-based. Findings should be interpreted according to peptide form, delivery vehicle, skin model, concentration, study duration, measurement method, and formulation stability.
Safety Considerations
Research discussion should account for topical formulation compatibility, skin irritation potential, penetration limitations, peptide stability, preservative system, supplier documentation, and laboratory handling procedures.
Use Restriction
Not for human or animal consumption. Not intended to diagnose, treat, cure, or prevent any disease when discussed as a research-use material.
Related Supplies
Research Supplies
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Bacteriostatic Water
Commonly referenced in laboratory preparation workflows.
Research Syringes
Supply category for controlled laboratory research preparation.
Prep Supplies
Supporting supplies for clean handling, preparation, and documentation.
Lab Handling
Handling & Storage
Storage
Store materials according to product-specific requirements. Protect from excessive heat, moisture, and direct light.
After Reconstitution
Keep refrigerated after reconstitution unless otherwise specified by the product documentation.
Handling
Use appropriate laboratory PPE, clean handling practices, and qualified research procedures.
Documentation
Maintain batch details, COA records, preparation notes, and internal research documentation.