Peptide Lab HQ Research Guide
Cortagen
A research-focused compound profile covering Cortagen identity, AEDP tetrapeptide research, cerebral cortex peptide bioregulator models, neuroregulatory pathway context, concentration reference, preparation reference, and safety considerations.
Compound Data
Compound Profile
| Compound Name | Cortagen |
|---|---|
| Common Research Name | AEDP tetrapeptide |
| Common Synonyms | Ala-Glu-Asp-Pro, Alanyl-glutamyl-aspartyl-proline, AEDP peptide, brain cortex tetrapeptide |
| Compound Type | Synthetic ultrashort tetrapeptide / peptide bioregulator research compound |
| PubChem CID | 18439621 |
| Amino Acid Length | 4 amino acids |
| Amino Acid Sequence | Ala-Glu-Asp-Pro |
| Short Sequence | AEDP |
| Molecular Formula | C₁₇H₂₆N₄O₉; verify against supplier COA |
| Molecular Weight | Approximately 430.41 g/mol; verify against supplier COA |
| Research Category | Peptide bioregulator, cerebral cortex peptide, neuroregulatory model, gene-expression, nerve-regeneration, cellular stress-response, and aging-marker research |
| Research Context | Commonly discussed in short-peptide bioregulator research involving nervous-system models, peripheral nerve regeneration, gene-expression patterns, and tissue-specific regulatory pathways. |
| Appearance | White to off-white lyophilized powder, depending on supplier documentation |
| Use | For laboratory research use only. |
Research Applications
Key Research Applications
Cortagen is commonly discussed in controlled research models involving AEDP tetrapeptide signaling, cerebral cortex peptide bioregulation, peripheral nerve regeneration, neuroregulatory pathways, cellular stress-response mechanisms, gene-expression activity, and aging-associated cellular markers.
Peptide Bioregulator Research
Cortagen is commonly positioned within ultrashort peptide bioregulator research, where short amino acid sequences are studied for tissue-specific signaling and gene-expression related effects.
Cerebral Cortex Peptide Models
Cortagen was developed from research involving brain cortex peptide preparations and is commonly discussed in nervous-system bioregulator contexts.
Nerve-Regeneration Research
Cortagen appears in preclinical peripheral nerve research involving sciatic nerve regeneration, nerve-fiber growth, and neural tissue response observations.
Gene-Expression Research
Cortagen has been evaluated in microarray-based research examining peptide-associated changes in gene-expression patterns.
Neuroprotection Context
Cortagen is discussed in research involving ischemia-related models, cellular stress response, and neuroprotective peptide activity.
Cellular Aging Marker Models
Short peptide bioregulator research commonly evaluates aging-associated markers, chromatin behavior, transcriptional activity, and tissue-specific cellular response.
Research Scope
These applications are provided for educational and research-reference purposes only. Cortagen research is limited compared with major peptide categories, and outcomes may vary based on sequence identity, purity, study model, concentration, exposure duration, and laboratory conditions.
Reference Only
Reconstitution / Research Dosing Reference
Quick Reference Summary
| Reference Vial | 20 mg Cortagen |
|---|---|
| Primary Solution Volume | 1.0 mL bacteriostatic water |
| Primary Concentration | 20 mg/mL |
| Measurement Reference | On a U-100 syringe, 1 unit = 0.01 mL. |
| Amount per U-100 Unit | At 20 mg/mL, 1 unit equals 0.2 mg / 200 mcg Cortagen. |
| Storage Reference | Refrigerate at 2–8°C / 35.6–46.4°F after reconstitution, protected from direct light. |
Reconstitution Steps
- Draw 1.0 mL bacteriostatic water using a sterile syringe for the main concentration reference shown below.
- Slowly add the BAC water down the side of the vial wall.
- Gently roll or swirl the vial until the material is completely dissolved. The solution should appear clear to slightly hazy depending on concentration and supplier format. Do not shake!
- Because this is a concentrated 20 mg/mL preparation, verify complete dissolution before recording final preparation details.
- Label with compound name, vial amount, concentration, solvent volume, preparation date, storage conditions, and handling notes.
- Store refrigerated at 2–8°C / 35.6–46.4°F, protected from direct light.
Published Research Context
| Reference Type | Reported Amount / Context | Research Notes |
|---|---|---|
| Compound Identity Reference | Cortagen, commonly referenced as AEDP / Ala-Glu-Asp-Pro | Cortagen is commonly discussed as a short synthetic tetrapeptide bioregulator associated with brain-cortex, neural-tissue, and tissue-specific regulatory research contexts. |
| Peptide Bioregulator Research | Model-dependent concentration and endpoint tracking | Commonly discussed in short-peptide bioregulator, DNA / chromatin interaction, gene-expression, cellular-response, and regulatory peptide research contexts. |
| Neuroprotective Research Context | Experimental neural and ischemia-model context | Cortagen-related research discussions commonly include neuroprotective markers, ischemia-model observations, neuronal-response markers, and brain-tissue regulatory endpoints. |
| Peripheral Nerve Research Context | Peripheral nerve tissue and regeneration-model context | Published research discussions have referenced Cortagen in peripheral nerve recovery, nerve-regeneration, post-injury tissue-response, and structural / functional recovery model contexts. |
| Gene-Expression Research Context | Short peptide / gene-expression marker context | Research literature has discussed Cortagen in relation to changes in gene-expression marker patterns, tissue-specific regulatory responses, and cellular pathway documentation depending on the model. |
| Cardiac / Systemic Marker Research | Experimental gene-expression and tissue-marker context | Cortagen has also appeared in research discussions involving gene-expression patterns in cardiac tissue and broader tissue-response marker observations. |
| Public Protocol-Style Reference | Milligram-range reference examples | Public protocol-style references commonly describe Cortagen in milligram-range examples. These are not clinical dosing standards. |
| Clinical / Research-Chemical Status | No universal research-chemical protocol established | Published study references, public protocol-style references, clinical-use references, or wellness protocols should not be treated as dosing instructions for research-chemical vial formats. |
Concentration Reference
| Vial Amount | Solution Volume | Final Concentration |
|---|---|---|
| 20 mg | 1.0 mL | 20 mg/mL |
Research Dosing Amount / Volume Reference
| Reference Amount | Volume at 20 mg/mL | U-100 Unit Reference | Approx. References per 20 mg Vial |
|---|---|---|---|
| 0.5 mg / 500 mcg | 0.025 mL | 2.5 units | 40 |
| 1 mg / 1000 mcg | 0.05 mL | 5 units | 20 |
| 2 mg / 2000 mcg | 0.10 mL | 10 units | 10 |
| 5 mg / 5000 mcg | 0.25 mL | 25 units | 4 |
| 10 mg / 10000 mcg | 0.50 mL | 50 units | 2 |
| 20 mg / 20000 mcg | 1.00 mL | 100 units | 1 |
Research Frequency / Amount Reference
| Research Window | Frequency | Reference Amount | Units / Volume Reference |
|---|---|---|---|
| Lower Conversion Reference | Public protocol-style reference, not a clinical dosing standard | 0.5 mg reference amount | 2.5 units / 0.025 mL |
| Standard Conversion Reference | Public protocol-style reference, not a clinical dosing standard | 1 mg reference amount | 5 units / 0.05 mL |
| Mid-Range Conversion Example | Calculation reference only | 2 mg reference amount | 10 units / 0.10 mL |
| Upper Conversion Example | Calculation reference only | 5 mg reference amount | 25 units / 0.25 mL |
| High Conversion Example | Calculation reference only | 10 mg reference amount | 50 units / 0.50 mL |
| Full-Vial Preparation Reference | Preparation-level calculation reference | 20 mg reference amount | 100 units / 1.00 mL |
Common Research Windows
| Reference Window | Common Length | Research Notes |
|---|---|---|
| Cell-Culture / Gene-Expression Window | 24–72 hours | May be used for gene-expression, neural-cell response, brain-tissue marker, oxidative-stress marker, cellular-aging marker, or peptide-response documentation depending on the model. |
| Acute Neural Observation Window | Single session to several days | Used for early response tracking, neuroprotective-marker comparison, ischemia-model observation, or short-term pathway documentation depending on the research design. |
| Short Research Window | 1–2 weeks | May be used for short-duration controlled observation involving neural-response markers, nerve-regeneration markers, post-injury tissue-response, or gene-expression endpoints. |
| Standard Protocol-Style Window | 2–4 weeks | Commonly used in public protocol-style references for structured observation and comparison across baseline and follow-up periods. |
| Extended Observation Window | 4–8 weeks | Used when longer documentation is needed for neural-response trends, peripheral nerve recovery markers, tissue-specific expression patterns, or follow-up marker tracking. |
| Follow-Up / Washout | 1–4 weeks | Used to document post-study observations, marker return, delayed response patterns, or follow-up data depending on the research model. |
Research Note: These tables are provided for educational, research-planning, concentration, frequency-reference, and volume-reference purposes only. Cortagen, commonly referenced as AEDP / Ala-Glu-Asp-Pro, is discussed in peptide bioregulator, brain-cortex, neural-tissue, neuroprotective, ischemia-model, nerve-regeneration, peripheral nerve recovery, gene-expression, DNA / chromatin interaction, and tissue-specific regulatory research contexts. This reference uses a 20 mg vial reconstituted with 1.0 mL bacteriostatic water, creating a 20 mg/mL concentration. Higher-concentration preparations may require supplier-specific handling, solvent-volume, or solubility notes; verify against the COA, batch record, or formula record when available. Published study references and public protocol-style frequency references are not universal research-chemical dosing standards and should not be treated as dosing instructions for research-chemical vial formats. This information is not medical advice, dosing instruction, injectable-use guidance, or a recommendation for human or animal use.
Research Notes
Research Findings & Safety Notes
Research Findings
Cortagen is commonly discussed in research involving ultrashort peptide bioregulation, AEDP tetrapeptide signaling, cerebral cortex peptide models, peripheral nerve regeneration, neuroregulatory pathways, gene-expression activity, and cellular stress-response mechanisms.
Study Limitations
Cortagen research is limited compared with major peptide categories and includes peptide bioregulator, preclinical nerve-response, gene-expression, and neuroprotection-related references. Findings should be interpreted according to peptide sequence, purity, model type, concentration, exposure duration, and endpoint selection.
Safety Considerations
Research discussion should account for peptide identity verification, AEDP sequence confirmation, sterility documentation, endotoxin risk, supplier qualification, batch records, storage conditions, and qualified laboratory handling procedures.
Use Restriction
Not for human or animal consumption. Not intended to diagnose, treat, cure, or prevent any disease when discussed as a research-use material.
Related Supplies
Research Supplies
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Bacteriostatic Water
Commonly referenced in laboratory preparation workflows.
Research Syringes
Supply category for controlled laboratory research preparation.
Prep Supplies
Supporting supplies for clean handling, preparation, and documentation.
Lab Handling
Handling & Storage
Storage
Store materials according to product-specific requirements. Protect from excessive heat, moisture, and direct light.
After Reconstitution
Keep refrigerated after reconstitution unless otherwise specified by the product documentation.
Handling
Use appropriate laboratory PPE, clean handling practices, and qualified research procedures.
Documentation
Maintain batch details, COA records, preparation notes, and internal research documentation.