Peptide Lab HQ Research Guide
PT-141
A research-focused compound profile covering PT-141 identity, melanocortin receptor research, Bremelanotide reference data, concentration reference, reconstitution reference, and safety considerations.
Compound Data
Compound Profile
| Compound Name | PT-141 |
|---|---|
| Generic Name | Bremelanotide |
| Compound Type | Synthetic cyclic heptapeptide / melanocortin receptor agonist |
| CAS Number | 189691-06-3 |
| PubChem CID | 9941379 |
| Amino Acid Length | 7 amino acids, cyclic peptide structure |
| Amino Acid Sequence | Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-OH |
| Molecular Formula | C₅₀H₆₈N₁₄O₁₀ |
| Molecular Weight | Approximately 1025.2 g/mol |
| Research Category | Melanocortin receptor, neuroendocrine, CNS signaling, sexual-function, and autonomic-response research |
| Appearance | White to off-white lyophilized powder |
| Use | For laboratory research use only. |
Research Applications
Key Research Applications
PT-141 is commonly discussed in controlled research models involving melanocortin receptor signaling, neuroendocrine response, CNS-mediated sexual-function pathways, autonomic-response markers, and hormone-independent arousal signaling.
Melanocortin Receptor Research
PT-141 is studied as a melanocortin receptor agonist, with research interest around MC3R and MC4R signaling pathways.
CNS Signaling Models
Used in research involving central nervous system signaling, neurobehavioral response, and brain-mediated arousal pathways.
Neuroendocrine Research
Relevant to research involving neuroendocrine modulation, autonomic response, and peptide-receptor signaling.
Sexual-Function Study Context
Bremelanotide has a prescription-product context for acquired, generalized HSDD in certain premenopausal women, separate from research-chemical vial references.
Autonomic Response Models
Discussed in research contexts involving blood-pressure response, heart-rate response, flushing, and other autonomic markers.
Peptide Analog Research
PT-141 is commonly discussed alongside melanocortin-family peptide analogs, including α-MSH-related and Melanotan-related research contexts.
Research Scope
These applications are provided for educational and research-reference purposes only. Research outcomes may vary based on study model, route, formulation, purity, concentration, and laboratory conditions.
Reference Only
Reconstitution / Research Dosing Reference
Quick Reference Summary
| Reference Vial | 10 mg PT-141 |
|---|---|
| Primary Solution Volume | 2.0 mL bacteriostatic water |
| Primary Concentration | 5 mg/mL |
| Measurement Reference | On a U-100 syringe, 1 unit = 0.01 mL. |
| Amount per U-100 Unit | At 5 mg/mL, 1 unit equals 0.05 mg / 50 mcg PT-141. |
| Storage Reference | Refrigerate at 2–8°C / 35.6–46.4°F after reconstitution, protected from direct light. |
Reconstitution Steps
- Draw 2.0 mL bacteriostatic water using a sterile syringe for the main concentration reference shown below.
- Slowly add the BAC water down the side of the vial wall.
- Gently roll or swirl the vial until the material is completely dissolved. The solution should appear clear. Do not shake!
- Label with compound name, vial amount, concentration, solvent volume, preparation date, storage conditions, and handling notes.
- Store refrigerated at 2–8°C / 35.6–46.4°F, protected from direct light.
Published Research Context
| Reference Type | Reported Amount / Context | Research Notes |
|---|---|---|
| Compound Identity Reference | PT-141, also commonly referenced as Bremelanotide | PT-141 is commonly discussed as a synthetic cyclic peptide analog of alpha-melanocyte-stimulating hormone used in melanocortin receptor research. |
| Melanocortin Receptor Research | Melanocortin receptor agonist context | Commonly discussed in MC3R, MC4R, melanocortin signaling, receptor-activation, CNS signaling, and pathway-response research contexts. |
| MC4R / CNS Research Context | Model-dependent concentration and endpoint tracking | PT-141 / Bremelanotide is frequently discussed in central melanocortin pathway research involving MC4R signaling, neuroendocrine response, arousal pathway models, and behavioral-response endpoints. |
| Sexual-Function Research Context | Clinical-study and experimental research context | Published research has evaluated PT-141 / Bremelanotide in sexual-function and arousal-response research models. These clinical-study contexts are not research-chemical dosing standards. |
| Alpha-MSH Analog Research | Cyclic peptide analog context | Commonly discussed alongside melanocortin peptides and alpha-MSH analogs, with attention to receptor subtype activity and central pathway response. |
| Public Protocol-Style Reference | Microgram-to-milligram reference examples | Public protocol-style references commonly describe PT-141 in microgram-to-milligram examples depending on the research model and preparation format. These are not clinical dosing standards. |
| Clinical / Research-Chemical Status | No universal research-chemical protocol established | Published study references, clinical-use references, public protocol-style references, or wellness protocols should not be treated as dosing instructions for research-chemical vial formats. |
Concentration Reference
| Vial Amount | Solution Volume | Final Concentration |
|---|---|---|
| 10 mg | 2.0 mL | 5 mg/mL |
Research Dosing Amount / Volume Reference
| Reference Amount | Volume at 5 mg/mL | U-100 Unit Reference | Approx. References per 10 mg Vial |
|---|---|---|---|
| 50 mcg | 0.01 mL | 1 unit | 200 |
| 100 mcg | 0.02 mL | 2 units | 100 |
| 0.25 mg / 250 mcg | 0.05 mL | 5 units | 40 |
| 0.5 mg / 500 mcg | 0.10 mL | 10 units | 20 |
| 1 mg / 1000 mcg | 0.20 mL | 20 units | 10 |
| 2 mg / 2000 mcg | 0.40 mL | 40 units | 5 |
| 5 mg / 5000 mcg | 1.00 mL | 100 units | 2 |
| 10 mg / 10000 mcg | 2.00 mL | 200 units | 1 |
Research Frequency / Amount Reference
| Research Window | Frequency | Reference Amount | Units / Volume Reference |
|---|---|---|---|
| Lower Microgram Reference | Calculation reference only | 50 mcg reference amount | 1 unit / 0.01 mL |
| Standard Microgram Reference | Public protocol-style reference, not a clinical dosing standard | 100 mcg reference amount | 2 units / 0.02 mL |
| Low Milligram Conversion Example | Public protocol-style reference, not a clinical dosing standard | 250 mcg reference amount | 5 units / 0.05 mL |
| Mid-Range Conversion Example | Calculation reference only | 0.5 mg reference amount | 10 units / 0.10 mL |
| Upper Conversion Example | Calculation reference only | 1 mg reference amount | 20 units / 0.20 mL |
| Preparation-Level Conversion Example | Calculation reference only | 2 mg reference amount | 40 units / 0.40 mL |
| Half-Vial Preparation Reference | Preparation-level calculation reference | 5 mg reference amount | 100 units / 1.00 mL |
| Full-Vial Preparation Reference | Preparation-level calculation reference | 10 mg reference amount | 200 units / 2.00 mL |
Common Research Windows
| Reference Window | Common Length | Research Notes |
|---|---|---|
| Cell-Culture / Receptor Observation Window | 24–72 hours | May be used for melanocortin receptor activation, receptor-binding, intracellular signaling, MC3R / MC4R pathway response, or cellular-response documentation depending on the model. |
| Acute Neuroendocrine Observation Window | Single session to several days | Used for short-term receptor-response timing, CNS pathway observation, neuroendocrine-marker tracking, behavioral-response documentation, or early pathway comparison depending on the research design. |
| Short Research Window | 1–2 weeks | May be used for early controlled observation involving melanocortin signaling, behavioral-response endpoints, arousal-pathway models, or neuroendocrine response markers. |
| Standard Protocol-Style Window | 2–4 weeks | Commonly used in public protocol-style references for structured observation and comparison across baseline and follow-up periods. |
| Extended Observation Window | 4–8 weeks | Used when longer documentation is needed for receptor-response trends, CNS pathway context, behavioral-model tracking, or follow-up marker comparison. |
| Follow-Up / Washout | 1–4 weeks | Used to document post-study observations, marker return, delayed response patterns, or follow-up data depending on the research model. |
Research Note: These tables are provided for educational, research-planning, concentration, frequency-reference, and volume-reference purposes only. PT-141, also known as Bremelanotide, is commonly discussed in melanocortin receptor, MC3R, MC4R, alpha-MSH analog, neuroendocrine, CNS pathway, behavioral-response, arousal-pathway, and receptor-signaling research contexts. This reference uses a 10 mg vial reconstituted with 2.0 mL bacteriostatic water. Published study references, clinical-use references, public protocol-style references, and wellness protocols are not universal research-chemical dosing standards and should not be treated as dosing instructions for research-chemical vial formats. This information is not medical advice, dosing instruction, injectable-use guidance, or a recommendation for human or animal use.
Research Notes
Research Findings & Safety Notes
Research Findings
PT-141 is commonly discussed in research involving melanocortin receptor activation, CNS-mediated sexual-function pathways, neuroendocrine response, and autonomic markers.
Study Limitations
PT-141 has a prescription-product context as bremelanotide, but research-chemical vial references should not be treated as interchangeable with prescription autoinjector products or clinical protocols.
Safety Considerations
Research discussion should account for blood-pressure response, heart-rate changes, nausea, flushing, focal hyperpigmentation, pregnancy considerations, and cardiovascular-risk screening.
Use Restriction
Not for human or animal consumption. Not intended to diagnose, treat, cure, or prevent any disease when discussed as a research-use material.
Related Supplies
Research Supplies
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Bacteriostatic Water
Commonly referenced in laboratory preparation workflows.
Research Syringes
Supply category for controlled laboratory research preparation.
Prep Supplies
Supporting supplies for clean handling, preparation, and documentation.
Lab Handling
Handling & Storage
Storage
Store materials according to product-specific requirements. Protect from excessive heat, moisture, and direct light.
After Reconstitution
Keep refrigerated after reconstitution unless otherwise specified by the product documentation.
Handling
Use appropriate laboratory PPE, clean handling practices, and qualified research procedures.
Documentation
Maintain batch details, COA records, preparation notes, and internal research documentation.