Peptide Lab HQ Research Guide
Ipamorelin
A research-focused compound profile covering Ipamorelin identity, ghrelin receptor research, growth hormone secretagogue activity, pituitary signaling, concentration reference, reconstitution reference, and safety considerations.
Compound Data
Compound Profile
| Compound Name | Ipamorelin |
|---|---|
| Research Code / Synonyms | NNC 26-0161, NNC-260161, Ipamorelin INN |
| Compound Type | Synthetic pentapeptide / growth hormone secretagogue / ghrelin receptor agonist |
| CAS Number | 170851-70-4 |
| UNII | Y9M3S784Z6 |
| Amino Acid Length | 5 amino acids |
| Amino Acid Sequence | Aib-His-D-2-Nal-D-Phe-Lys-NH₂ |
| Molecular Formula | C₃₈H₄₉N₉O₅ |
| Molecular Weight | Approximately 711.85 g/mol |
| Research Category | Growth hormone secretagogue, ghrelin receptor, GHSR, pituitary signaling, GH-axis, and endocrine-marker research |
| Appearance | White to off-white lyophilized powder |
| Use | For laboratory research use only. |
Research Applications
Key Research Applications
Ipamorelin is commonly discussed in controlled research models involving ghrelin receptor signaling, growth hormone secretagogue activity, pituitary response, growth hormone release, endocrine-marker tracking, and GH-axis pathway research.
Ghrelin Receptor Research
Ipamorelin is studied as a ghrelin mimetic that binds the growth hormone secretagogue receptor, also known as GHSR.
Growth Hormone Secretagogue Models
Used in research involving selective growth hormone release, pituitary signaling, and endocrine response documentation.
Pituitary Signaling Research
Relevant to models evaluating pituitary response, growth hormone pulse behavior, and secretagogue-mediated hormone release.
Endocrine Selectivity Models
Ipamorelin is commonly discussed for its selective GH-release profile compared with earlier growth hormone-releasing peptides.
Combination Research Context
Frequently discussed alongside GHRH analogs such as CJC-1295 w/o DAC because the two compounds act through different GH-axis signaling pathways.
Metabolic & Body-Composition Research
GH-secretagogue research is often connected with body-composition, recovery-marker, metabolic-marker, and endocrine-axis study models.
Research Scope
These applications are provided for educational and research-reference purposes only. Research outcomes may vary based on study model, route, peptide purity, timing, concentration, and laboratory conditions.
Reference Only
Reconstitution / Research Dosing Reference
Select Reference Vial
Select a vial size to update the concentration, U-100 unit references, and frequency table below.
Quick Reference Summary
| Reference Vial | 2 mg Ipamorelin |
|---|---|
| Primary Solution Volume | 2 mL bacteriostatic water |
| Primary Concentration | 1 mg/mL |
| Measurement Reference | On a U-100 syringe, 1 unit = 0.01 mL. |
| Amount per U-100 Unit | At 1 mg/mL, 1 unit equals 0.01 mg / 10 mcg Ipamorelin. |
| Storage Reference | Refrigerate at 2–8°C / 35.6–46.4°F after reconstitution, protected from direct light. |
Reconstitution Steps
- Draw 2 mL bacteriostatic water using a sterile syringe for the main concentration reference shown below.
- Slowly add the BAC water down the side of the vial wall.
- Gently roll or swirl the vial until the material is completely dissolved. The solution should appear clear. Do not shake!
- Label with compound name, vial amount, concentration, solvent volume, preparation date, storage conditions, and handling notes.
- Store refrigerated at 2–8°C / 35.6–46.4°F, protected from direct light.
Published Research Context
| Reference Type | Reported Amount / Context | Research Notes |
|---|---|---|
| Compound Identity Reference | Ipamorelin, also referenced as NNC 26-0161 | Ipamorelin is commonly described as a pentapeptide ghrelin mimetic and selective growth hormone secretagogue. |
| Ghrelin-Receptor Research | Model-dependent concentration and endpoint tracking | Commonly discussed in ghrelin receptor, growth hormone secretagogue receptor, pituitary-response, and GH-release contexts. |
| Selective Secretagogue Context | Selective GH-release research model | Research literature commonly discusses Ipamorelin as a selective growth hormone secretagogue compared with broader GHRP-family compounds. |
| Public Protocol-Style Reference | Microgram-range reference examples | Public protocol-style references are not clinical dosing standards and should not be treated as research-chemical use instructions. |
| Clinical / Research-Chemical Status | No universal research-chemical protocol established | Published study references, public protocol-style references, clinical-use references, or wellness protocols should not be treated as dosing instructions for research-chemical vial formats. |
Concentration Reference
| Vial Amount | Solution Volume | Final Concentration |
|---|---|---|
| 2 mg | 2 mL | 1 mg/mL |
| 5 mg | 2 mL | 2.5 mg/mL |
| 10 mg | 2 mL | 5 mg/mL |
Research Dosing Amount / Volume Reference
| Reference Amount | Volume at 1 mg/mL | U-100 Unit Reference | Approx. References per 2 mg Vial |
|---|---|---|---|
| 50 mcg | 0.05 mL | 5 units | 40 |
| 0.1 mg / 100 mcg | 0.10 mL | 10 units | 20 |
| 0.2 mg / 200 mcg | 0.20 mL | 20 units | 10 |
| 0.25 mg / 250 mcg | 0.25 mL | 25 units | 8 |
| 0.5 mg / 500 mcg | 0.50 mL | 50 units | 4 |
| 1 mg / 1000 mcg | 1.00 mL | 100 units | 2 |
| 2 mg / 2000 mcg | 2.00 mL | 200 units | 1 |
| 5 mg / 5000 mcg | 5.00 mL | 500 units | 0.4 |
| 10 mg / 10000 mcg | 10.00 mL | 1000 units | 0.2 |
Research Frequency / Amount Reference
| Research Window | Frequency | Reference Amount | Units / Volume Reference |
|---|---|---|---|
| Lower Conversion Reference | Public protocol-style reference, not a clinical dosing standard | 50 mcg reference amount | 5 units / 0.05 mL |
| Low-to-Mid Conversion Reference | Public protocol-style reference, not a clinical dosing standard | 0.1 mg / 100 mcg reference amount | 10 units / 0.10 mL |
| Standard Conversion Reference | Public protocol-style reference, not a clinical dosing standard | 0.2 mg / 200 mcg reference amount | 20 units / 0.20 mL |
| Mid-Range Conversion Example | Public protocol-style reference, not a clinical dosing standard | 0.25 mg / 250 mcg reference amount | 25 units / 0.25 mL |
| Upper Conversion Example | Public protocol-style reference, not a clinical dosing standard | 0.5 mg / 500 mcg reference amount | 50 units / 0.50 mL |
| High Conversion Example | Public protocol-style reference, not a clinical dosing standard | 1 mg / 1000 mcg reference amount | 100 units / 1.00 mL |
Common Research Windows
| Reference Window | Common Length | Research Notes |
|---|---|---|
| Cell-Culture / Marker Observation Window | 24–72 hours | May be used for receptor-response, pituitary-cell, GH-release, endocrine-marker, or cellular-signaling documentation depending on the model. |
| Acute Observation Window | Single session to several days | Used for short-term response tracking, timing comparison, early marker observation, or preparation comparison depending on the research design. |
| Short Research Window | 1–2 weeks | May be used for early controlled observation involving GH-release, IGF-1 pathway context, metabolic markers, or endocrine-response markers. |
| Standard Protocol-Style Window | 2–4 weeks | Commonly used in public protocol-style references for structured observation and comparison across baseline and follow-up periods. |
| Extended Observation Window | 4–8 weeks | Used when longer documentation is needed for endocrine-marker trends, receptor-response patterns, metabolic-marker comparison, or follow-up marker tracking. |
| Follow-Up / Washout | 1–4 weeks | Used to document post-study observations, marker return, delayed response patterns, or follow-up data depending on the research model. |
Research Note: These tables are provided for educational, research-planning, concentration, frequency-reference, and volume-reference purposes only. Ipamorelin is commonly discussed in ghrelin-receptor, growth hormone secretagogue, pituitary-response, GH-release, selective secretagogue, neuroendocrine-marker, and metabolic-marker research contexts. The selector above updates calculations for 2 mg, 5 mg, and 10 mg vial references, each reconstituted with 2.0 mL bacteriostatic water. Published study references and public protocol-style frequency references are not universal research-chemical dosing standards and should not be treated as dosing instructions for research-chemical vial formats. This information is not medical advice, dosing instruction, injectable-use guidance, or a recommendation for human or animal use.
Research Notes
Research Findings & Safety Notes
Research Findings
Ipamorelin is commonly discussed in research involving ghrelin receptor signaling, selective growth hormone release, pituitary response, GH-axis activity, endocrine-marker tracking, and growth hormone secretagogue models.
Endocrine Selectivity
Published pharmacology research reported that Ipamorelin stimulated GH release while showing limited ACTH and cortisol response compared with certain earlier GHRP compounds.
Safety Considerations
Research discussion should account for GH-axis activity, IGF-1 response, glucose-related markers, water retention, appetite-related observations, injection-site response, and endocrine feedback monitoring.
Use Restriction
Not for human or animal consumption. Not intended to diagnose, treat, cure, or prevent any disease when discussed as a research-use material.
Related Supplies
Research Supplies
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Bacteriostatic Water
Commonly referenced in laboratory preparation workflows.
Research Syringes
Supply category for controlled laboratory research preparation.
Prep Supplies
Supporting supplies for clean handling, preparation, and documentation.
Lab Handling
Handling & Storage
Storage
Store materials according to product-specific requirements. Protect from excessive heat, moisture, and direct light.
After Reconstitution
Keep refrigerated after reconstitution unless otherwise specified by the product documentation.
Handling
Use appropriate laboratory PPE, clean handling practices, and qualified research procedures.
Documentation
Maintain batch details, COA records, preparation notes, and internal research documentation.