Peptide Lab HQ Research Guide
Kisspeptin-10
A research-focused compound profile covering Kisspeptin-10 identity, KISS1/GPR54 pathway research, reproductive-axis signaling, GnRH/LH response models, concentration reference, reconstitution reference, and safety considerations.
Compound Data
Compound Profile
| Compound Name | Kisspeptin-10 |
|---|---|
| Common Synonyms | Kisspeptin-10 human, Metastin 45-54, KISS-1 112-121, KP-10 |
| Compound Type | Synthetic decapeptide / KISS1 receptor agonist research peptide |
| CAS Number | 374675-21-5 |
| PubChem CID | 25240297 |
| Amino Acid Length | 10 amino acids |
| Amino Acid Sequence | Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH₂ |
| Short Sequence | YNWNSFGLRF-NH₂ |
| Molecular Formula | C₆₃H₈₃N₁₇O₁₄ |
| Molecular Weight | Approximately 1302.4 g/mol |
| Research Category | KISS1/GPR54 receptor, GnRH signaling, LH/FSH response, reproductive-axis, neuroendocrine, fertility, and metabolic research |
| Appearance | White to off-white lyophilized powder |
| Use | For laboratory research use only. |
Research Applications
Key Research Applications
Kisspeptin-10 is commonly discussed in controlled research models involving KISS1 receptor activation, GnRH neuron signaling, LH and FSH response, reproductive-axis regulation, puberty signaling, fertility-related models, neuroendocrine feedback, and metabolic-reproductive pathway interactions.
KISS1 / GPR54 Research
Kisspeptin-10 is studied as an active kisspeptin fragment interacting with the KISS1 receptor, also referred to as GPR54.
GnRH Signaling Models
Used in research involving upstream stimulation of GnRH neurons and downstream reproductive hormone signaling.
LH / FSH Response Research
Human and animal studies commonly evaluate Kisspeptin-10 through luteinizing hormone and follicle-stimulating hormone response patterns.
Reproductive-Axis Research
Relevant to research involving hypothalamic-pituitary-gonadal axis signaling, puberty biology, gonadotropin release, and reproductive endocrine feedback.
Fertility Study Context
Kisspeptin pathway research is commonly discussed in fertility, ovulation, hypothalamic amenorrhea, and gonadotropin-response study contexts.
Metabolic-Reproductive Models
Kisspeptin signaling is also studied in models connecting energy balance, metabolic status, and reproductive hormone regulation.
Research Scope
These applications are provided for educational and research-reference purposes only. Research outcomes may vary based on dose, route, sex, cycle phase, baseline endocrine status, study model, peptide purity, concentration, and laboratory conditions.
Reference Only
Reconstitution / Research Dosing Reference
Select Reference Vial
Select a vial size to update the concentration, U-100 unit references, and frequency table below.
Quick Reference Summary
| Reference Vial | 5 mg Kisspeptin-10 |
|---|---|
| Primary Solution Volume | 2 mL bacteriostatic water |
| Primary Concentration | 2.5 mg/mL |
| Measurement Reference | On a U-100 syringe, 1 unit = 0.01 mL. |
| Amount per U-100 Unit | At 2.5 mg/mL, 1 unit equals 0.025 mg / 25 mcg Kisspeptin-10. |
| Storage Reference | Refrigerate at 2–8°C / 35.6–46.4°F after reconstitution, protected from direct light. |
Reconstitution Steps
- Draw 2 mL bacteriostatic water using a sterile syringe for the main concentration reference shown below.
- Slowly add the BAC water down the side of the vial wall.
- Gently roll or swirl the vial until the material is completely dissolved. The solution should appear clear. Do not shake!
- Label with compound name, vial amount, concentration, solvent volume, preparation date, storage conditions, and handling notes.
- Store refrigerated at 2–8°C / 35.6–46.4°F, protected from direct light.
Published Research Context
| Reference Type | Reported Amount / Context | Research Notes |
|---|---|---|
| Compound Identity Reference | Kisspeptin-10, also referenced as human metastin 45–54 | Kisspeptin-10 is commonly identified as a KISS1-derived decapeptide and one of the shorter active kisspeptin fragments. |
| KISS1R / GPR54 Research | Model-dependent concentration and endpoint tracking | Commonly discussed in KISS1 receptor, GPR54 receptor, receptor activation, intracellular calcium, and neuroendocrine signaling contexts. |
| GnRH / Gonadotropin-Axis Research | Model-dependent endocrine-marker context | Kisspeptin signaling is commonly discussed in relation to GnRH neuron activation, LH/FSH marker response, and reproductive-axis regulation. |
| Public Protocol-Style Reference | Microgram-range reference examples | Public protocol-style references are not clinical dosing standards and should not be treated as research-chemical use instructions. |
| Clinical / Research-Chemical Status | No universal research-chemical protocol established | Published study references, public protocol-style references, clinical-use references, or wellness protocols should not be treated as dosing instructions for research-chemical vial formats. |
Concentration Reference
| Vial Amount | Solution Volume | Final Concentration |
|---|---|---|
| 5 mg | 2 mL | 2.5 mg/mL |
| 10 mg | 2 mL | 5 mg/mL |
Research Dosing Amount / Volume Reference
| Reference Amount | Volume at 2.5 mg/mL | U-100 Unit Reference | Approx. References per 5 mg Vial |
|---|---|---|---|
| 50 mcg | 0.02 mL | 2 units | 100 |
| 0.1 mg / 100 mcg | 0.04 mL | 4 units | 50 |
| 0.2 mg / 200 mcg | 0.08 mL | 8 units | 25 |
| 0.25 mg / 250 mcg | 0.10 mL | 10 units | 20 |
| 0.5 mg / 500 mcg | 0.20 mL | 20 units | 10 |
| 1 mg / 1000 mcg | 0.40 mL | 40 units | 5 |
| 2 mg / 2000 mcg | 0.80 mL | 80 units | 2.5 |
| 5 mg / 5000 mcg | 2.00 mL | 200 units | 1 |
| 10 mg / 10000 mcg | 4.00 mL | 400 units | 0.5 |
Research Frequency / Amount Reference
| Research Window | Frequency | Reference Amount | Units / Volume Reference |
|---|---|---|---|
| Lower Conversion Reference | Public protocol-style reference, not a clinical dosing standard | 50 mcg reference amount | 2 units / 0.02 mL |
| Low-to-Mid Conversion Reference | Public protocol-style reference, not a clinical dosing standard | 0.1 mg / 100 mcg reference amount | 4 units / 0.04 mL |
| Standard Conversion Reference | Public protocol-style reference, not a clinical dosing standard | 0.2 mg / 200 mcg reference amount | 8 units / 0.08 mL |
| Mid-Range Conversion Example | Public protocol-style reference, not a clinical dosing standard | 0.25 mg / 250 mcg reference amount | 10 units / 0.10 mL |
| Upper Conversion Example | Public protocol-style reference, not a clinical dosing standard | 0.5 mg / 500 mcg reference amount | 20 units / 0.20 mL |
| High Conversion Example | Public protocol-style reference, not a clinical dosing standard | 1 mg / 1000 mcg reference amount | 40 units / 0.40 mL |
Common Research Windows
| Reference Window | Common Length | Research Notes |
|---|---|---|
| Cell-Culture / Marker Observation Window | 24–72 hours | May be used for KISS1R / GPR54 signaling, calcium-response, receptor-activation, cell-migration, or invasion-marker documentation depending on the model. |
| Acute Observation Window | Single session to several days | Used for short-term response tracking, timing comparison, early marker observation, or preparation comparison depending on the research design. |
| Short Research Window | 1–2 weeks | May be used for early controlled observation involving reproductive-axis, receptor-response, trophoblast, or migration markers. |
| Standard Protocol-Style Window | 2–4 weeks | Commonly used in public protocol-style references for structured observation and comparison across baseline and follow-up periods. |
| Extended Observation Window | 4–8 weeks | Used when longer documentation is needed for reproductive-axis trends, receptor-response patterns, tumor-biology markers, or follow-up marker tracking. |
| Follow-Up / Washout | 1–4 weeks | Used to document post-study observations, marker return, delayed response patterns, or follow-up data depending on the research model. |
Research Note: These tables are provided for educational, research-planning, concentration, frequency-reference, and volume-reference purposes only. Kisspeptin-10 is commonly discussed in KISS1R / GPR54 receptor, GnRH neuron, LH/FSH, reproductive-axis, trophoblast, cell-migration, invasion-marker, and metastasis-related research contexts. The selector above updates calculations for 5 mg and 10 mg vial references, each reconstituted with 2.0 mL bacteriostatic water. Published study references and public protocol-style frequency references are not universal research-chemical dosing standards and should not be treated as dosing instructions for research-chemical vial formats. This information is not medical advice, dosing instruction, injectable-use guidance, or a recommendation for human or animal use.
Research Notes
Research Findings & Safety Notes
Research Findings
Kisspeptin-10 is commonly discussed in research involving KISS1 receptor activation, GnRH neuron signaling, LH and FSH response, reproductive-axis regulation, fertility study models, and endocrine feedback loops.
Study Limitations
Kisspeptin-10 research includes human endocrine studies, infusion studies, animal models, and mechanistic reproductive-axis research. Findings should be interpreted according to dose, route, sex, cycle phase, and baseline endocrine status.
Safety Considerations
Research discussion should account for endocrine-axis activity, LH and FSH response, sex-hormone changes, fertility-related endpoints, study timing, and qualified laboratory handling procedures.
Use Restriction
Not for human or animal consumption. Not intended to diagnose, treat, cure, or prevent any disease when discussed as a research-use material.
Related Supplies
Research Supplies
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Bacteriostatic Water
Commonly referenced in laboratory preparation workflows.
Research Syringes
Supply category for controlled laboratory research preparation.
Prep Supplies
Supporting supplies for clean handling, preparation, and documentation.
Lab Handling
Handling & Storage
Storage
Store materials according to product-specific requirements. Protect from excessive heat, moisture, and direct light.
After Reconstitution
Keep refrigerated after reconstitution unless otherwise specified by the product documentation.
Handling
Use appropriate laboratory PPE, clean handling practices, and qualified research procedures.
Documentation
Maintain batch details, COA records, preparation notes, and internal research documentation.